![]() ![]() Derivation and validation of weightings were conducted with generalized additive models adjusted for age, gender and hospital types. Charlson and van Walraven weights were applied to Charlson and Elixhauser comorbidity indices. To derive the Swiss weightings for the Elixhauser comorbidity index, we randomly halved the inpatient data and validated the results of part 1 alongside the established weighting systems in part 2, to predict in-hospital mortality. Retrospective analysis was conducted with routine data of 102 Swiss general hospitals (2012–2017) for 6.09 million inpatient cases. ![]() The present study, therefore, aimed to derive a set of new Swiss Elixhauser comorbidity weightings, to validate and compare them against those of the Charlson and Elixhauser-based van Walraven weights in an adult in-patient population-based cohort of general hospitals. Still, a different set of comorbidity weights might improve the prediction of in-hospital mortality. The Charlson and Elixhauser comorbidity indices are well-established for risk adjustment and mortality prediction. ![]() Understanding how comorbidity measures contribute to patient mortality is essential both to describe patient health status and to adjust for risks and potential confounding. ![]()
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